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Articles & Research
from hVIVO
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1 - 10 of 47 posts
Scientific Paper
02 May 2024
Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single centre, open-label, phase 1 controlled human infection study
A SARS-CoV-2 controlled human infection model (CHIM) has been successfully established in seronegative individuals using a dose of 1×101 50% tissue culture infectious dose (TCID50) pre-alpha SARS-CoV-2 virus. Given the...
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Case Study
20 Mar 2024
SARS-CoV-2 Human Challenge Study
At the start of the Covid pandemic, as the world leader in human challenge studies, hVIVO acted as prime contractor in a UK Government funded consortium tasked with setting up...
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Blog
13 Mar 2024
Human Challenge Trials for Tropical Diseases: Not as exotic as one might think
Introduction Despite scientific progress made in the last decades, nearly 1 billion of individuals are affected by tropical diseases yearly, according to the World Health Organization. The development of new...
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Scientific Paper
13 Feb 2024
Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults
Co-authored by Alexander Mann – Senior Director of Clinical Science, Andrew Catchpole – Chief Scientific Officer, Mariya Kalinova – Medical Director
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Case Study
09 Jan 2024
Influenza Phase IIa Challenge Study Case Study
hVIVO were contracted by a US-based clinical-stage biopharmaceutical company to conduct an Influenza Phase IIa challenge study with their investigational product. Their lead candidate was a first-in-class, broadly neutralising anti-influenza...
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Blog
23 Oct 2023
The UK Regulatory Competitiveness in an ever changing world
Clinical research success during the COVID-19 pandemic The United Kingdom, with its rich history of clinical trials, has long been a preferred destination for conducting cutting-edge research. One of the...
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Factsheet
10 Oct 2023
Human Challenge Clinical Trials Factsheet
World leader in testing infectious and respiratory disease products using human challenge clinical trials. Read more to see the benefits of a human challenge trial and what human challenge models...
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Article
11 Sep 2023
Pharma Focus Asia, Issue 52, 2023 – Human Challenge Trials: Establishing early risk-benefit in development of vaccines and therapies for infectious diseases
Featured on pages 54-56
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Scientific Paper
14 Jun 2023
Viral emissions into the air and environment after SARS-CoV-2 human challenge: a phase 1, open label, first-in-human study
Effectively implementing strategies to curb SARS-CoV-2 transmission requires understanding who is contagious and when. Although viral load on upper respiratory swabs has commonly been used to infer contagiousness, measuring viral...
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Blog
12 Jun 2023
Why are Biotech’s & Pharma Using Human Challenge Studies for Drug Development?
What is a human challenge study? In a human challenge study, healthy volunteers are intentionally infected with a virus/bacteria or parasite in a quarantine facility. The volunteers are monitored under...
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